Rapid and accurate simultaneous determination of fosinopril sodium and hydrochlorothiazide in tablets by HPLC

A new, simple, precise, accurate, and rapid reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultan eous determination of fosinopril sodium and hydrochlorothiazide from-tablet s. The procedure is based on the use of the RP-HPLC method with a UV detect or. Each analysis requires no longer than 6 minutes. A reversed phase C-18 column with a mobile phase composed of a mixture of methanol: water (40.60, v/v), adjusted to pH 4 with 10% orthophosphoric acid, was used to separate both compounds with sulfamethoxazole, as an internal standard, in a reason able time period. The linearity range for fosinopril sodium and hydrochlorothiazide was 1.6-3 0 mug/mL and 1-30 mug/mL, respectively. The detection limits for fosinopril sodium and hydrochlorothiazide were 0.29 mug/mL and 0.26 mug/mL, respectiv ely.