Ion interaction chromatography of neutral molecules. use of a potential approximation to obtain a simplified retention equation

The chromatographic behavior of neutral molecules in Ion Interaction Chroma tography (IIC) was theoretically investigated. The use of a potential appro ximation to obtain a simplified retention equation was successfully tested. The most reliable experimental literature results, concerning the retentio n behavior of neutral molecules in IIC, were successfully fitted by the ret ention equation. The wide variability among them was elucidated on the basis of the develope d retention equation. A new separation strategy, to improve the selectivity of the chromatographic method, for difficult to separate mixtures of neutr al eluates was proposed.