Integration of the PRB and p53 cell cycle control pathways

Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the observation that members of these pathways a re found mutated in all human cancer. These two pathways have typically bee n studied and described independently. However, as we discuss here, recent data have revealed an intimate molecular and genetic interaction between th e p53 and pRB pathways.