Rapid homogeneous-phase Sonogashira coupling reactions using controlled microwave heating

Authors
Erdelyi, M Gogoll, A
Citation
M. Erdelyi et A. Gogoll, Rapid homogeneous-phase Sonogashira coupling reactions using controlled microwave heating, J ORG CHEM, 66(12), 2001, pp. 4165-4169
Citations number
34
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
66
Issue
12
Year of publication
2001
Pages
4165 - 4169
Database
ISI
SICI code
0022-3263(20010615)66:12<4165:RHSCRU>2.0.ZU;2-S
Abstract
A microwave-enhanced, rapid and efficient homogeneous-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of a ryl iodides, bromides, triflates, and aryl chloride, as well as pyridine an d thiophene derivatives with trimethylsilylacetylene. Excellent yields (80- 95%) for substrates containing a large variety of substituents in different positions are obtained in 5-25 min.