Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea

Objective: We tested the hypothesis that a 6-week course of a nasal glucoco rticoid spray would decrease the severity of obstructive sleep apnea in chi ldren with adenotonsillar hypertrophy. Study design: We conducted a randomized, triple-blind, placebo-controlled, parallel-group trial of nasal fluticasone propionate versus placebo in 25 c hildren aged 1 to 10 years with obstructive sleep apnea proven on polysomno graphy. The primary outcome was the change from baseline in the frequency o f mixed and obstructive apneas and hypopneas. Results: Thirteen children received fluticasone, and 12 received placebo. T he mixed/obstructive apnea/hypopnea index decreased from 10.7 +/- 2.6 (SE) to 5.8 +/- 2.2 in the fluticasone group but increased from 10.9 +/- 2.3 to 13.1 +/- 3.6 in the placebo group, P = .04. The mixed/obstructive apnea/hyp opnea index decreased in 12 of 13 subjects treated with fluticasone versus 6 of 12 treated with placebo, P = .03. The frequencies of hemoglobin desatu ration and respiratory movement/arousals also decreased more in the flutica sone group. Changes from baseline in tonsillar size, adenoidal size, and sy mptom score were not significantly different between groups. Conclusion: Nasal fluticasone decreased the frequency of mixed and obstruct ive e apneas and hypopneas, suggesting that topical corticosteroids may be helpful in ameliorating pediatric obstructive sleep apnea.