Reversed-phase high-performance liquid chromatography (RP-HPLC) determination of lipophilicity of furocoumarins. Relationship with DNA interaction

Authors
Caffieri, S
Citation
S. Caffieri, Reversed-phase high-performance liquid chromatography (RP-HPLC) determination of lipophilicity of furocoumarins. Relationship with DNA interaction, J PHARM SCI, 90(6), 2001, pp. 732-739
Citations number
36
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN journal
00223549 → ACNP
Volume
90
Issue
6
Year of publication
2001
Pages
732 - 739
Database
ISI
SICI code
0022-3549(200106)90:6<732:RHLC(D>2.0.ZU;2-Y
Abstract
The partition coefficient (P) of 82 furocoumarins and analogs (psoralens, a ngelicins, allopsoralens, 8-azapsoralens, angular furoquinolin-2-ones, sulf ur and selenium isosters of psoralen and angelicin) has been determined by reversed-phase HPLC. The chromatographic behavior correlates well with the in vitro affinity of the compounds toward DNA. (C) 2001 Wiley-Liss, Inc. an d the American Pharmaceutical Association J Pharm Sci 90:732-739, 2001.