S. Caffieri, Reversed-phase high-performance liquid chromatography (RP-HPLC) determination of lipophilicity of furocoumarins. Relationship with DNA interaction, J PHARM SCI, 90(6), 2001, pp. 732-739
The partition coefficient (P) of 82 furocoumarins and analogs (psoralens, a
ngelicins, allopsoralens, 8-azapsoralens, angular furoquinolin-2-ones, sulf
ur and selenium isosters of psoralen and angelicin) has been determined by
reversed-phase HPLC. The chromatographic behavior correlates well with the
in vitro affinity of the compounds toward DNA. (C) 2001 Wiley-Liss, Inc. an
d the American Pharmaceutical Association J Pharm Sci 90:732-739, 2001.