Use of NMR and mass spectrometry in establishing the structures of ring opening products of 3-methyl-4,1-benzoxazepine-2,5-dione in acid and basic media

Authors
Alam, S Baber, ZUD Khan, N
Citation
S. Alam et al., Use of NMR and mass spectrometry in establishing the structures of ring opening products of 3-methyl-4,1-benzoxazepine-2,5-dione in acid and basic media, J CHEM S P, 22(4), 2000, pp. 299-302
Citations number
12
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
ISSN journal
02535106 → ACNP
Volume
22
Issue
4
Year of publication
2000
Pages
299 - 302
Database
ISI
SICI code
0253-5106(200012)22:4<299:UONAMS>2.0.ZU;2-#
Abstract
3-Methyl-4,1-benzoxazepine-2.5-dione (I) when stirred for lr hours in metha nolic solution with a few drops of 10 %. NaOH below 60 degreesC gave solid crystalline product (m.p. 100-102 degreesC, 51% yield). H-1 NMR and MS anal ysis confirmed structure (II) which suggest the cleavage of C-O bond but wh en (I) was treated with a few drops of 10% HCl under similar temperature yi elded compound (III) as a liquid which gave evidence for C-N bond cleavage giving no traces of the former product (II).