Comments on rupture of absorbed vesicles

We, treat rupture of adsorbed vesicles by using elements of the fracture th eory. This approach allows us to estimate the rupture rate constant and, in analogy with the conventional purely thermodynamical analysis, to introduc e the critical value of the lipid-substrate interaction and the critical ve sicle size for vesicle rupture. In:our treatment, these values are however related to the kinetics and accordingly they are dependent (logarithmically ) on the time scale of the experiment.