HELICOBACTER-PYLORI SURVIVAL IN GASTRIC-MUCOSA BY GENERATION OF A PH GRADIENT

Helicobacter pylori has been established as the major causative agent of human active gastritis and is an essential factor in peptic ulcer d isease and gastric cancer. The mechanism that has been proposed for H. pylori to control its inhospitable microenvironment happens to coinci de with the pH control technique developed by us. This technique was d eveloped to separate an acidic environment from a basic environment fo r a sequential enzymatic reaction by the hydrolysis of urea within a t hin layer of immobilized urease. In this paper, a mathematical model i s presented to consider how H. pylori survives the gastric acidity. Th e computed results explain well the experimental data available involv ing H. pylori.