Authors
Citation
M. Freeman, Pin-pointing MAPK signalling, NAT CELL BI, 3(6), 2001, pp. E136-E137
Citations number
13
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
14657392
→ ACNP
Volume
3
Issue
6
Year of publication
2001
Pages
E136 - E137
Database
ISI
SICI code
1465-7392(200106)3:6<E136:PMS>2.0.ZU;2-M
Abstract
In the Drosophila egg, during signalling through the epidermal growth facto
r (EGF) receptor, a conformational switch, which is dependent on mitogen-ac
tivated protein kinase (MAPK) leads to the Cf2 transcriptional repressor be
ing targeted for proteolysis. Recent work shows that this switch is catalys
ed by the Drosophila homologue of Pin1, a peptidyl-prolyl isomerase.