Objective: The purpose of this study was to investigate the effectiveness o
f caries removal by using an Er:YAG laser irradiation with and without Cari
solv (TM), in vitro. Background Data: Effective ablation of dental hard tis
sues using Er:YAG Laser has been reported and its application to caries rem
oval has been expected. Methods: Five extracted human teeth were selected f
or Carisolv (TM) and burr treatment. One-half of the lesion was treated wit
h the Carisolv (TM) and then removed. The other half was removed using burr
treatment. Fifty teeth were subjected to Er:YAG laser treatment with and w
ithout Carisolv (TM). First, Carisolv (TM) was applied on one-half of each
carious lesions for 1 min and followed by the Er:YAG laser irradiation at 6
0-140 mJ, 2 Hz for another 1 min; the other half was treated with Er:YAG la
ser only. The cavity was carefully assessed by DIAGNOdent. Each lesion was
photographed before and after treatment, and the treated cavity was observe
d by microscopy and with scanning electron microscope (SEM). Results: Our r
esults revealed that application of Carisolv (TM) followed by Er:YAG laser
irradiation at 100-140 mJ pulse energy effectively removed dentin caries. F
rom the SEM study, it was found that the cavity surface treated with the la
ser revealed various patterns of microirregularity, often accompanied by mi
crofissure propagation. There was also no smear layer. Conclusions: It was
revealed that Er:YAG laser and Carisolv (TM) could provide an alternative t
echnique for caries removal for conventional mechanical drilling and cuttin
g.