ROPIVACAINE 0.75-PERCENT FOR EXTRADURAL ANESTHESIA IN ELECTIVE CESAREAN-SECTION - AN OPEN CLINICAL AND PHARMACOKINETIC STUDY IN MOTHER AND NEONATE

Authors
MORTON CPJ BLOOMFIELD S MAGNUSSON A JOZWIAK H MCCLURE JH
Citation
Cpj. Morton et al., ROPIVACAINE 0.75-PERCENT FOR EXTRADURAL ANESTHESIA IN ELECTIVE CESAREAN-SECTION - AN OPEN CLINICAL AND PHARMACOKINETIC STUDY IN MOTHER AND NEONATE, British Journal of Anaesthesia, 79(1), 1997, pp. 3-8
Citations number
22
Categorie Soggetti
Anesthesiology
Journal title
British Journal of Anaesthesia → ACNP
ISSN journal
00070912
Volume
79
Issue
1
Year of publication
1997
Pages
3 - 8
Database
ISI
SICI code
0007-0912(1997)79:1<3:R0FEAI>2.0.ZU;2-C
Abstract
In an open study we have investigated the efficacy of 20 ml of 0.75% r opivacaine (7.5 mg ml(-1)) to provide extradural anaesthesia for elect ive Caesarean section. Plasma concentrations (total and free) were est imated in the mother and neonate. Anaesthesia was effective and safe. Plasma concentrations of ropivacaine in the mother and neonate were wi thin safe limits and consistent with previous studies. Two mothers rec eived accidental i.v. injections of ropivacaine 75 mg and 150 mg, resp ectively, without serious adverse effects.