N. Mader et al., DYSTROPHIN-DEFICIENT MDX MUSCLE IS NOT PRONE TO MH SUSCEPTIBILITY - AN IN-VITRO STUDY, British Journal of Anaesthesia, 79(1), 1997, pp. 125-127
The association between malignant hyperthermia (MH) and neuromuscular
disorders is controversial. An association between MH and Duchenne mus
cular dystrophy, a common and lethal disorder caused by deficiency of
dystrophin, has been reported sporadically but is still not proved. To
examine this problem, we performed halothane and caffeine in vitro co
ntracture tests on skeletal muscles from dystrophin deficient mdx mice
, an animal model for human Duchenne muscular dystrophy. As neither ha
lothane nor caffeine triggered abnormal responses in mdx muscles, we c
onclude that dystrophin deficiency per se is not the primary cause of
MH-like crises, as reported for patients with Duchenne muscular dystro
phy.