Microtubule motors, phosphorylation and axonal transport of neurofilaments

The recent demonstration that the axonal transport motors kinesin and dynei n participate in axonal transport of neurofilaments (NFs), and that the ass ociation of NFs with these motors is regulated by phosphorylation provides new insight into several aspects of axonal transport and NF biology. This r eview juxtaposes older and more recent findings on NF dynamics, and specula tes on the organization of axonal NFs as suggested by real-time analyses of NF transport.