Linear IgA dermatosis presenting with erythema annulare centrifugum lesions: report of three cases in adults

Linear IgA dermatosis presented with erythema annulare centrifugum lesions in three elderly women. Search for underlying malignancy revealed low-grade B-cell lymphoma in one case. In addition to subepidermal blistering, histo logy showed a typical mixed infiltrate of granulocytes and eosinophils and, occasionally, papillar microabsesses in one case. In the two other subject s, characteristic subepidermal lining with granulocytes was observed. Immun ofluorescence studies confirmed the diagnosis, while autoantibodies charact eristic for dermatitis herpetiformis were absent To our knowledge this is t he second report of adult linear IgA dermatosis in association with erythem a annulare centrifugum lesions. Our observations concord with several other reports of figurate erythema associated with autoimmune blistering disease and other immune disorders. Common antibody-related immunological mechanis ms indicate that the two distinct clinical pictures are probably stages of the same pathogenic entity.