Spectrophotometric determination of fluvoxamine maleate and fluoxetine hydrochloride

Authors
Starczewska, B
Citation
B. Starczewska, Spectrophotometric determination of fluvoxamine maleate and fluoxetine hydrochloride, J TR MICROP, 19(1), 2001, pp. 19-24
Citations number
11
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF TRACE AND MICROPROBE TECHNIQUES
ISSN journal
07334680 → ACNP
Volume
19
Issue
1
Year of publication
2001
Pages
19 - 24
Database
ISI
SICI code
0733-4680(2001)19:1<19:SDOFMA>2.0.ZU;2-Z
Abstract
Fluvoxamine maleate and fluoxetine hydrochloride react with eriochrome cyan ine R and form pink ion-association compounds. These compounds are insolubl e in water, but fairly soluble in organic solvents. Addition of methylcellu lose affects the solubility of the compounds and increases the absorbance o f the solution. Optimal reaction conditions have been established, and a ne w spectrophotometric method has been developed for the determination of flu voxamine and fluoxetine in the concentration ranges 0.6-15 and 0.3-5.0 mug/ cm(3) respectively.