The oral bioavailability of ibuprofen enantiomers in broiler chickens

Doses of racemic ibuprofen ranging from 5 to 20 mg/kg body weight were admi nistered intravenously (i.v.) and orally to broiler chickens and plasma con centration-time profiles for both ibuprofen enantiomers were determined, Th e absorption of ibuprofen was evaluated after a bolus administration of a c ommercially available suspension into the crop and proventriculus, respecti vely. An enterohepatic circulation as described for other nonsteroidal anti inflammatory drugs (NSAIDs) in other species could be suggested for both en antiomers after i.v. and oral administration. Significantly higher area und er the curve (AUC) values for S(+)-ibuprofen compared with R(-)-ibuprofen w ere collected after crop and proventriculus administration. Several factors could be responsible for the significant differences in AUC values between both enantiomers.