Effects of lysine clonixinate on platelet function. Comparison with other non-steroid anti-inflammatory drugs.

One of the mechanisms of action of non steroid antiinflammatory drugs (NSAI Ds) consists of inhibition of prostaglandin synthesis. This explains many o f the pharmacological effects and adverse events observed in medical practi ce. Administration of NSAIDs to patients with hemostatic disorders or perio perative conditions entails the risk of bleeding due to inhibition of plate let function. This study deals with platelet changes induced by lysine clon ixinate vs diclofenac, ibuprofen and aspirin in classical tests such as pla telet count, platelet factor 3 (PF3) activity and platelet aggregation with various inductors and more recent procedures such as P-selectin measuremen t by flow cytometry. Unlike control drugs, lysine clonixinate did not induc e changes in platelet count or function when administered to healthy volunt eers at the commonly used therapeutic doses.