Maximal exercise and muscle energy metabolism after recovery from exercisehyperthermia syndrome

Muscle energy metabolism was studied in 30 subjects after recovery from exe rcise hyperthermia syndrome (EHTS subjects) and 15 healthy men with identic al physical activities. Blood lactate. free fatty acid (FFA), serum creatin e kinase activity (CK), and glycerol and the temperature in the auditory du ct (T-c) and on the thumb pad (T-sk) were measured at rest and during and a fter maximal exercise on a cycloergometer. The EHTS subjects had a limitati on of physical performance. with lowered values for maximal oxygen uptake ( VO2max P < 0.0005), maximal workload (P < 0.05), and ventilatory threshold (V-t, P < 0.0005), The discrepancy between high plasma concentrations of FF A and the lack of decrease in respiratory ratio (RR) suggests that, in EHTS subjects, a very active release of FFA was not balanced by a proportional increase in catabolism. The increased skin tem perature was smaller in EHTS subjects (P < 0.05 at 180 and 200 W). At the end of exercise, auditory duc t temperature increase was higher in EHTS subjects than in control subjects (P < 0.05). This study thus showed an impairment of muscle metabolism and an abnormality of thermoregulatory mechanisms. These results may provide in sight into the underlying physiopathological disturbance. (C) 2001 John Wil ey & Sons, Inc.