H. Wamhoff et al., Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of 7-substituted isothiazolo[4,5-d]pyrimidine C-nucleosides, NUCLEOS NUC, 20(3), 2001, pp. 229-241
The Divakar-Reese procedure has been successfully applied for transforming
7-oxo-isothiazolo[4,5-d]pyrimidine C-nucleosides (4a,b, 5a,b, 6a) via 1,2,4
-triazol-1-yl intermediates (7a,b, 8a,b) into various 7-substituted C-nucle
osides 15a,b, 16a,b, 17a, 18a, 19a,b, 20a,b; their subsequent deprotection
provides novel types of unusual C-glycosides 22b, 23a, 24a,b, 25b, 26b.
C-Nucleosides, possessing on its heterocyclic base other than naturally occ
uring oxo- or amino substituents, are important model compounds for biologi
cal or medicinal studies (2,3). We want to report on the synthesis of novel
7-substituted isothiazolo = [4,5-d]pyrimidine C-nucleosides. As we could s
how in previous papers (1,4), there exists a simple approach to the protect
ed C-glycosides 4-6.