A neural network to predict melting temperature (T-m) of RNA duplex

Authors
Cheng, CM Ma, LX Miyajima, H Herdewijn, P
Citation
Cm. Cheng et al., A neural network to predict melting temperature (T-m) of RNA duplex, NUCLEOS NUC, 20(3), 2001, pp. 261-269
Citations number
6
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
3
Year of publication
2001
Pages
261 - 269
Database
ISI
SICI code
1525-7770(2001)20:3<261:ANNTPM>2.0.ZU;2-1
Abstract
A straightforward method to predict RNA duplex stability by neural network is described. The best network consists of three layers in which the input layer units are 12 (frequencies of 10 nearest-neighbors and 2 terminals), t he hidden layer units are 3 and the output layer unit is 1 (measured T-m). This method to predict T-m has the advantage that the determinations of the rmodynamic parameters is not needed.