Risk factors for cardiovascular disease in children with type I diabetes

Background: The major cause of morbidity and mortality in individuals with Type I insulin-dependent diabetes mellitus (IDDM) is premature and extensiv e atherosclerotic cardiovascular disease (CVD). Objectives: To determine the prevalence and predictors of hypercholesterole mia and to examine the distribution and interrelationship of risk factors f or CVD. Methods: This observational (mixed-longitudinal) study, guided by an epidem iologic framework, assessed a sample of 140 children with IDDM. Total chole sterol (TC) and diabetes control were measured in the total sample. Standar d CVD risk factors were measured in a subsample of 67 children. Results: Observed frequency of TC greater than the 75th percentile and grea ter than the 95th percentile was significantly more than expected (p < 0.01 and p < 0.0001, respectively). In the total sample, TC-CVD risk factor ass ociations were not observed. However, diabetes control and physical activit y were correlated with TC in the risk sample of children at highest risk, a s demonstrated by hypercholesterolemia. Conclusions: Results demonstrate the importance of assessing the lipid prof ile in children with IDDM and monitoring CVD risk factors in hyperlipidemic children with IDDM. Future research should focus on prospective longitudin al studies in population-based multiethnic samples of children with IDDM.