K. Kozaki et al., Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis, ONCOGENE, 20(31), 2001, pp. 4228-4234
This study established and characterized low-metastatic revertant and paren
tal clones of a highly metastatic human lung cancer cell line, NCI-H460-LNM
35 (hereafter referred to as LNM35), Expression-profiling analysis revealed
that up-regulation of various proinflammatory cytokines and angiogenic che
motactic chemokines was present in LNM35, Further, while COX-2 itself is kn
own to be inducible in inflammation, COX-2 expression levels correlated wel
l with the capabilities of these clones for not only in vitro motility and
invasion but also in vivo metastasis, and COX-2 inhibitors were shown for t
he first time to reduce lung cancer metastasis in vivo. These findings sugg
est that lung cancer cells may mimic inflammatory cells in the process of m
etastasis.