Py. Le Berre et al., Comparison of recovery after intermediate duration of anaesthesia with sevoflurane and isoflurane, PAEDIATR AN, 11(4), 2001, pp. 443-448
Background: The purpose of this study was to compare recovery from anaesthe
sia after sevoflurane and isoflurane were administered to children for more
than 90 min.
Methods: After parental informed consent and ethical committee approval, ch
ildren aged between 2 months and 6 years, ASA I or II, were randomly alloca
ted to sevoflurane (n = 20) or isoflurane (n = 20) groups. Halogenated agen
ts were discontinued following skin closure and patients were ventilated me
chanically with 100% oxygen until minimum alveolar concentration (MAC) valu
es awake were obtained (endtidal concentrations 0.6 MAC for sevoflurane and
0.4 MAC for isoflurane). Effective perioperative analgesia was provided by
a caudal block.
Results: The mean (+/- SD) duration of anaesthesia was 132 +/- 38 min and 1
39 +/- 49 min for sevoflurane and isoflurane, respectively. Early recovery
occurred sooner in the isoflurane group (time to extubation was 16 +/- 7 mi
n and 11 +/- 5 min, P<0.01; Aldrete's score at 0 min was 5.5 +/- 1.5 and 7.
4 +/- 1.8, P<0.001, respectively). But the time to be fit for discharge fro
m recovery room was similar at 136 +/- 18 min and 140 +/- 20 min, respectiv
ely.
Conclusions: After intermediate duration of anaesthesia administered to chi
ldren for up to 90 min, isoflurane and sevoflurane allow recovery after app
roximatively the same lapse of time.