Improving bioavailability and anthelmintic activity of albendazole by preparing albendazole-cyclodextrin complexes

The bioavailability and anthelmintic activity of albendazole cyclodextrin c omplexes (ABZ-CDC) compared to albendazole suspensions in carboxymethylcell ulose (ABZ-CMC) was assessed in a mouse model for Trichinella infections. S wiss CD-I mice experimentally infected with T.spiralis were treated with bo th formulations against enteral (adult worms) and parenteral (migrating and encysted larvae). Oral bioavailability was assessed in age matched mice tr eated with 50 mg/kg of both formulations. The anthelmintic effects and plas ma concentration of the active metabolite albendozole-sulphoxide (ABZSO) en antiomer (-) were significantly increased following administration of ABZ-C DC in relation to ABZ-CDC.