Efficacy of flubendazole and albendazole against Trichinella spiralis in mice

Efficacy of flubendazole and albendazole against Trichinella spiralis in mi ce were studied. ICR mice were experimentally infected with Trichinella spi ralis and treated with either flubendazole (FBZ) or albendazole (ABZ) at fo ur different stages of the parasite life-cycle. Oral administration of eith er FBZ or ABZ at 20 mg/kg and 50 mg/kg on 2 h, 8 h and 24 h (pre-adult stag e) after infection eliminated 94.7 similar to 100 % of adults as determined at necropsy on day 7 post infection (p.i.) and 96.9 similar to 100 % of la rvae on day 45 p.i. FBZ was more effective than ABZ against adult T, spiral is (at 2 to 6 days p.i.), when treated with a dosage of 20 mg/kg for 5 cons ecutive days (99.4% and 46.0 % reduction with respect to the control group) . Against migrating larval T, spiralis, FBZ was more effective than ABZ at 20 mg/kg for five consecutive days ton days 11 similar to 15 p.i.), and the reduction rate of recovered larvae were 99.6 % (FBZ) and 80.8 % (ABZ) resp ectively. FBZ was more effective against early encapsulated larval T spiral is (at 21 to 25 days p.i.), than ABZ when both were given at 20 mg/kg for f ive consecutive days (99.8 % and 45.4 % reduction, respectively). In conclu sion, flubendazole was more effective than albendazole against adult and pa renteral stages of Trichinella spiralis in mice.