We present two cases of adolescents who presented with painless scrotal mas
ses suggestive of testicular cancer. Diagnostic workup of both these patien
ts revealed Chlamydia trachomatis and both patients were successfully treat
ed with doxycycline. Both patients initially denied sexual activity. We sug
gest that a high index of suspicion is warranted in adolescent patients tha
t present with asymptomatic scrotal masses and precise tests for C. trachom
atis be done to rule out an infectious cause.