EFFECT OF TAUROHYODEOXYCHOLIC ACID ON BILIARY LIPID SECRETION IN MAN - PRELIMINARY-REPORT

Taurohyodeoxycholic acid and tauroursodeoxycholic acid were infused in traduodenally at a rate of 0.8 gk for three hours in 3 cholecystectomi zed T-tube patients, Biliary lipid secretion and bile acid composition were evaluated before and after replacement of the endogenous bile ac id pool with the two bile acids. As compared to basal values (2.78+/-1 .67 mM/l), taurohyodeoxycholic acid induced a greater increase in the biliary concentration of phospholipids (4.12+/-1.23 mM/l) as compared to tauroursodeoxycholic acid (3.14+/-0.98 mM/l). Biliary cholesterol c oncentration after taurohyodeoxycholic acid (1.89+/-0.63 mM/l) was unc hanged as compared to the pretreatment period (1.98+/-0.58 mM/l), whil e it decreased significantly after tauroursodeoxycholic acid (0.85+/-0 .08 mM/l). Biliary cholesterol secreted per unit of bile acid was grea ter during taurohyodeoxycholic acid than during tauroursodeoxycholic a cid, while the opposite was observed for the secretion of phospholipid s.