Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates

Authors
Tanganelli, S Fuxe, K Antonelli, T O'Connor, WT Ferraro, L
Citation
S. Tanganelli et al., Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates, PEPTIDES, 22(8), 2001, pp. 1229-1234
Citations number
33
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
22
Issue
8
Year of publication
2001
Pages
1229 - 1234
Database
ISI
SICI code
0196-9781(200108)22:8<1229:CIITNA>2.0.ZU;2-U
Abstract
The present article reviews our recent biochemical and microdialysis studie s showing the evidence for an antagonistic CCKB/D-2 receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and G ABAergic transmission in the ipsilateral ventral pallidum. Since the nucleu s accumbens plays a crucial role in regulating the output from the limbic s ystem and consequently motivation, it may be speculated that a dysregulatio n of this receptor interaction may have consequences in a wide range of cen tral nervous system disorders. (C) 2001 Elsevier Science Inc. All rights re served.