Cholecystokinin-8 (CCK-8) has no effect on heart rate in rats lacking CCK-A receptors

Authors
Kurosawa, M Iijima, S Funakoshi, A Kawanami, T Miyasaka, K Bucinskaite, V Lundeberg, T
Citation
M. Kurosawa et al., Cholecystokinin-8 (CCK-8) has no effect on heart rate in rats lacking CCK-A receptors, PEPTIDES, 22(8), 2001, pp. 1279-1284
Citations number
23
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
22
Issue
8
Year of publication
2001
Pages
1279 - 1284
Database
ISI
SICI code
0196-9781(200108)22:8<1279:C(HNEO>2.0.ZU;2-L
Abstract
Heart rate responses to i.v. administration of cholecystokinin-8 (CCK-8) we re investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking C CK-A receptors and control Long-Evens Tokushima Orsuka (LETO) rats. The hea rt rate decreased after i.v. administration of 3 nmol.kg(-1) of CCK-8 in LE TO rats, but not in OLETF rats, Bradycardia in the LETO rats disappeared af ter treatment with MK-329, but not after treatment with L-365,260. The expr ession of CCK-A receptor precursor mRNA was found exclusively in the atrium in LETO rats. These results suggest that CCK-8 decreases heart rate via CC K-A receptors located in the atrium of the rats. (C) 2001 Elsevier Science Inc. All rights reserved.