OLETF (Otsuka Long-Evans Tokushima Fatty) rats that lack the CCK 1 (A) receptor develop less behavioral sensitization to repeated cocaine treatment than wild type LETO (Long Evans Tokushima Otsuka) rats

Authors
Beinfeld, MC Connolly, K Pierce, RC
Citation
Mc. Beinfeld et al., OLETF (Otsuka Long-Evans Tokushima Fatty) rats that lack the CCK 1 (A) receptor develop less behavioral sensitization to repeated cocaine treatment than wild type LETO (Long Evans Tokushima Otsuka) rats, PEPTIDES, 22(8), 2001, pp. 1285-1290
Citations number
36
Categorie Soggetti
Biochemistry & Biophysics
Journal title
PEPTIDES
ISSN journal
01969781 → ACNP
Volume
22
Issue
8
Year of publication
2001
Pages
1285 - 1290
Database
ISI
SICI code
0196-9781(200108)22:8<1285:O(LTFR>2.0.ZU;2-F
Abstract
OLETF (Otsuka Long-Evens Tokushima Fatty) lacking the CCK 1 (A) receptor ha ve similar spontaneous activity and locomotor response (horizontal and vert ical activity) in response to a single injection of cocaine as the wild typ e LETO (Long Evans Tokushima Otsuka) rats. In contrast, the OLETF rats disp lay more stereotypy in response to the first dose of cocaine than the LETO rats. Tested at 7 and 14 days after a one week daily treatment with cocaine , the LETO rats display robust behavioral sensitization to cocaine while th e OLETF rats did not. These results support the hypothesis that endogenous CCK released by cocaine treatment and acting at CCK 1 receptors is required for the development and/or expression of this behavior. (C) 2001 Elsevier Science Inc. All rights reserved.