It is well known that Abraham Lincoln took a medicine called "blue mass" or
"blue pill," commonly prescribed in the 19th century. What is now hardly k
nown is that the main ingredient of blue mass was finely dispersed elementa
l mercury. As his friends understood, mercury was often prescribed for mela
ncholy or "hypochondriasis:" a condition Lincoln famously endured. Mercury
in the form of the blue pill is a potential neurotoxin, which we have demon
strated by recreating and testing the recipe. We present the testimony of m
any of Lincoln's contemporaries to suggest that Lincoln suffered the neurob
ehavioural consequences of mercury intoxication but, perhaps crucial to his
tory, before the main years of his presidency; he was astute enough to reco
gnize the effects and stop the medication soon after his inauguration.