Observations and modeling of synchronized bursting in two-dimensional neural networks - art. no. 011920

We present long-term (similar to hours) measurements of the spontaneous act ivity of two-dimensional cortical cell neural networks placed on multielect rode arrays. We compare histograms of single neuron interspike intervals an d the network intersynchronized bursting events intervals. In addition, the effect of Ca concentration on the network activity is being studied. At 1 mM Ca concentration, the network exhibits periodic synchronized bursting th at fades away after about 20 min. We present a feedback-regulated integrate and fire model to account for the observations. In the model we include tw o additional features: dynamical threshold and synapse fatigue.