Pseudoxanthoma elasticum (PXE) is a rare genetic disorder clinically charac
terized by skin, cardiovascular and eve manifestations, mainly due to calci
fication and fragmentation of elastic fibres. although infrequent, complica
tions during pregnancy in nomen affected by PXE have been reported. The aim
of the present stud! was to compare structural features of placentae at te
rm from 14 control and 15 PXE-affected nomen, in order to better understand
if and hen: abnormal mineral and/or matrix accumulation might affect place
ntal function in PSE. In all cases, pregnancy, fetus growth and delivery we
re normal. Both gross and light microscopy examination did not reveal drama
tic differences between placentae of PSE patients and controls, with regard
to weight, dimensions, infarcts, thrombi, inflammatory lesions or vessels.
However, necrotic changes and mineralization appealed statistically more p
ronounced in PXE. By electron microscopy the most remarkable differences be
tween PXE and control placentae were observed in the localization and morph
ology of mineral precipitates; a significant higher deposition of mineral p
recipitates was observed associated with the 'matrix'-type fibrinoid and am
ong collagen fibrils, especially on the maternal side. Immunocytochemistry
revealed the presence of vitronectin and fibronectin associated with the PX
E-specific mineralizations and the absence of mineralization on the small a
nd scarce elastic fibres in either controls or in PXE. (C) 2001 Harcourt Pu
blishers Ltd.