Distribution of amino acid residues and residue-residue contacts in molecular chaperones

The amino acid distribution and residue-residue contacts in molecular chape rones are different when compared to normal globular proteins. The study of molecular chaperones reveals a different surrounding environment to exist for the residues Cys, Trp, and His which may play an important role in dete rmining the chaperone structures. Unlike globular proteins, it has been obs erved that a one-to-one correspondence between the amino acid distribution in a sequence and the structures of molecular chaperones. The preference of amino acid residues surrounding all 20 types of residues in secondary stru ctures and their accessible surface areas have been analysed.