Nf. Bondar et al., Synthesis and dehydration of endo-2-(3-R-isoxazol-5-yl)-1,7,7-trimethylbicyclo[2.2.1]heptan-exo-2-ols, RUSS J ORG, 37(1), 2001, pp. 23-28
endo-2-Ethynyl-1,7,7-trimethyibicyclo[2.2.1]heptan-exo-2-ol reacts with nit
rile oxides, yielding endo-2-(3-R-isoxazol-5-yl)-1,7,7-trimethylbicyclo[2.2
.1]heptan-exo-2-ols. Treatment of the latter with methanesulfonyl chloride
in pyridine leads to dehydration and Formation of mixtures of the correspon
ding 1-(3-R-isoxazol-5-yl)-3,3-dimethyl-2-methylenebicyclo[2.2.1]heptanes a
nd 2-(3-R-isoxazol-5-yl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-enes at a rati
o of 2:1.