Management of Crigler-Najjar syndrome type I

Crigler-Najjar Syndrome type I is a rare congenital disease with high morta lity and morbidity rates due to brain complications. It has been treated by life-long phototherapy until the era of liver transplantation. Liver trans plantation is currently the only curative treatment for this syndrome. Live r transplantation prevents the severe neurological complications that are t he main cause of life-long disability in Crigler-Najjar Syndrome type I. Th e ideal age for transplantation is 3-5 years. Despite the advent of auxilia ry transplantation we believe that orthotopic liver transplantation is the optimal treatment and the ideal method of liver transplantation for Crigler -Najjar Syndrome type I.