Neuroimaging of declarative memory in schizophrenia

The past three decades have seen tremendous growth in our understanding of the cerebral underpinnings of schizophrenia, including the neural correlate s of the cognitive impairment seen in this syndrome. In this article we rev iew the role that structural and functional neuroimaging has played in eluc idating the cerebral basis for the declarative memory deficits associated w ith schizophrenia. Memory impairment in schizophrenia appears to involve ab normal connectivity between the prefrontal cortex and three regions importa nt in normal learning and memory: the hippocampus, thalamus, and cerebellum .