Botulinum toxin type A (BOTOX) for treatment of migraine

Citation
Wj. Binder et al., Botulinum toxin type A (BOTOX) for treatment of migraine, SEM CUT M S, 20(2), 2001, pp. 93-100
Citations number
53
Categorie Soggetti
Dermatology
Journal title
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
ISSN journal
10855629 → ACNP
Volume
20
Issue
2
Year of publication
2001
Pages
93 - 100
Database
ISI
SICI code
1085-5629(200106)20:2<93:BTTA(F>2.0.ZU;2-N
Abstract
An open-label study and 2 double-blind, placebo-controlled studies have pro vided supporting evidence of botulinum toxin type A (BTX-A) as an effective , well-tolerated treatment for migraine. Observed durations of benefit were consistent with known properties of BTX-A, Findings suggest that response may vary by features of preinjection headaches, such as migraine frequency. The precise mechanism by which BTX-A provides pain relief is hypothesized to be related not only to acetylcholine inhibition but also to a blocking a ction on the parasympathetic nervous system. Additional studies that contro l factors likely to be related to response may lead to better understanding of the BTX-A effect on migraine and an optimal treatment protocol. Copyrig ht (C) 2001 by W,B. Saunders Company.