Formulation of high tensile strength rapidly disintegrating tablets - Evaluation of the effect of some binder properties

Different combinations of binder, compound and a superdisintegrant (with a swelling mechanism) were studied to ascertain which binder properties were important in obtaining rapidly disintegrating tablets, which also had high tensile strength. Generally, without the addition of a superdisintegrant, t ablets with a high tensile strength were associated with a longer disintegr ation rime. The time taken for the tablets to disintegrate was generally re duced on the addition of a superdisintegrant. However rite effectiveness of the the superdisintegrant was dependent on the nature of the compound and binder i.e. the tablet microstructure surrounding the disintegrant particle s. Thus, the addition of deformable binders such as polyethylene glycol and amorphous lactose impaired the effect of the swelling disintegrant. In con trast, wizen using a more fragmenting binder such as MCC, the addition of a superdisintegrant had a pronounced effect. Furthermore, rite addition of b inders with high aqueous solubility or the use of soluble compounds seemed to also reduce the effectiveness of a superdisintegrant.