Spongidepsin, a new cytotoxic macrolide from Spongia sp.

Authors
Grassia, A Bruno, I Debitus, C Marzocco, S Pinto, A Gomez-Paloma, L Riccio, R
Citation
A. Grassia et al., Spongidepsin, a new cytotoxic macrolide from Spongia sp., TETRAHEDRON, 57(29), 2001, pp. 6257-6260
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
29
Year of publication
2001
Pages
6257 - 6260
Database
ISI
SICI code
0040-4020(20010716)57:29<6257:SANCMF>2.0.ZU;2-F
Abstract
A novel macrolide, spongidepsin (1) has been isolated from the Vanuatu mari ne sponge Spongia sp. The structure of 1, which contains 9-hydroxy-2,4,7-tr imethyltetradeca-14-ynoic acid and N-methylphenylalanine residues joined in a 13-membered ring, was elucidated by spectroscopic analysis. Spongidepsin (1) showed cytotoxic activity against J774.A1, WEHI-164 and HEK-293 cancer cell lines with an IC50 in the sub-micromolar range. (C) 2001 Elsevier Sci ence Ltd. All rights reserved.