Synthesis of amino alcohols on solid support via sulfonium-ion mediated Darzens reaction

Authors
Peschke, B Bundgaard, JG Breinholt, J
Citation
B. Peschke et al., Synthesis of amino alcohols on solid support via sulfonium-ion mediated Darzens reaction, TETRAHEDR L, 42(30), 2001, pp. 5127-5130
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
30
Year of publication
2001
Pages
5127 - 5130
Database
ISI
SICI code
0040-4039(20010723)42:30<5127:SOAAOS>2.0.ZU;2-V
Abstract
Epoxides were synthesized on a solid support via an immobilized sulfonium s alt, which is generated from a bromoacetic amide. Subsequent ring opening w ith amines leads to a single diastereoisomer of an amino alcohol, which can be cleaved from the solid support. (C) 2001 Elsevier Science Ltd. All righ ts reserved.