Chiral beta- and gamma-aminoalcohols derived from (+)-camphor and (-)-fenchone as catalysts for the enantioselective addition of diethylzinc to benzaldehyde
V. Dimitrov et al., Chiral beta- and gamma-aminoalcohols derived from (+)-camphor and (-)-fenchone as catalysts for the enantioselective addition of diethylzinc to benzaldehyde, TETRAHEDR-A, 12(9), 2001, pp. 1323-1329
The addition of Me3SiCN and LICH2CN to (+)-camphor and (-)-fenchone. respec
tively, followed by reduction leads to chiral beta- and gamma -aminoalcohol
s. The enantioselectivities realized using these aminoalcohols as ligands i
n the addition of Et2Zn to benzaldehyde were lower than those obtained usin
g the corresponding delta -aminoalcohols. (C) 2001 Elsevier Science Ltd. Al
l rights reserved.