Chiral beta- and gamma-aminoalcohols derived from (+)-camphor and (-)-fenchone as catalysts for the enantioselective addition of diethylzinc to benzaldehyde

Authors
Dimitrov, V Dobrikov, G Genov, M
Citation
V. Dimitrov et al., Chiral beta- and gamma-aminoalcohols derived from (+)-camphor and (-)-fenchone as catalysts for the enantioselective addition of diethylzinc to benzaldehyde, TETRAHEDR-A, 12(9), 2001, pp. 1323-1329
Citations number
38
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
9
Year of publication
2001
Pages
1323 - 1329
Database
ISI
SICI code
0957-4166(20010611)12:9<1323:CBAGDF>2.0.ZU;2-X
Abstract
The addition of Me3SiCN and LICH2CN to (+)-camphor and (-)-fenchone. respec tively, followed by reduction leads to chiral beta- and gamma -aminoalcohol s. The enantioselectivities realized using these aminoalcohols as ligands i n the addition of Et2Zn to benzaldehyde were lower than those obtained usin g the corresponding delta -aminoalcohols. (C) 2001 Elsevier Science Ltd. Al l rights reserved.