Haemostatic genetic risk factors in arterial thrombosis

Citation
Re. Simmonds et al., Haemostatic genetic risk factors in arterial thrombosis, THROMB HAEM, 86(1), 2001, pp. 374-385
Citations number
128
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
THROMBOSIS AND HAEMOSTASIS
ISSN journal
03406245 → ACNP
Volume
86
Issue
1
Year of publication
2001
Pages
374 - 385
Database
ISI
SICI code
0340-6245(200107)86:1<374:HGRFIA>2.0.ZU;2-4
Abstract
Haemostasis plays an integral role in arterial thrombotic disease. However, establishing which of the factors are risk factors has proven surprisingly difficult. Because of its technical simplicity and digital nature, the stu dy of haemostatic polymorphisms as risk factors has grown in popularity. On ce established as a risk factor, a genetic polymorphism has the potential t o aid selective prophylaxis and therapy of disease. Numerous reports have n ow been published on polymorphisms of coagulation and fibrinolytic factors, of coagulation and fibrinolytic inhibitory proteins, and of platelet membr ane glycoprotein receptors. This article describes the polymorphisms and ev aluates the results of these studies using the premises of consistency of w ithin-report genotype/phenotype/disease relationships and consistency of ou tcome between studies. Many studies have been only of association between p olymorphisms and disease, a type of study that is prone to error. Furthermo re, the collective outcome of these studies has primarily been inconsistent . It is concluded that despite the early promise of polymorphisms as risk f actors, fresh approaches differing in scale and design are now required to clarify their possible importance.