Fishing for lymphoid genes

Citation
Ns. Trede et al., Fishing for lymphoid genes, TRENDS IMMU, 22(6), 2001, pp. 302-307
Citations number
41
Categorie Soggetti
Immunology
Journal title
TRENDS IN IMMUNOLOGY
ISSN journal
14714906 → ACNP
Volume
22
Issue
6
Year of publication
2001
Pages
302 - 307
Database
ISI
SICI code
1471-4906(200106)22:6<302:FFLG>2.0.ZU;2-T
Abstract
Thymic organogenesis and T-cell lymphopoiesis are crucial interdependent pr ocesses that establish a functional vertebrate immune system. The current u nderstanding of vertebrate thymic development during embryogenesis remains incomplete and would benefit from novel approaches. The zebrafish Danio rer io is a powerful developmental and genetic system for the dissection of ear ly events in the ontogeny of the immune system. Forward genetic screens hav e uncovered genes involved in hematopoiesis, and specific screens are being designed to examine the genes that regulate T-cell development and the ori gin of the thymus. Studies of the zebrafish should improve our understandin g of lymphoid development in vertebrates.