Fibroblasts regulate the switch from acute resolving to chronic persistentinflammation

Authors
Buckley, CD Pilling, D Lord, JM Akbar, AN Scheel-Toellner, D Salmon, M
Citation
Cd. Buckley et al., Fibroblasts regulate the switch from acute resolving to chronic persistentinflammation, TRENDS IMMU, 22(4), 2001, pp. 199-204
Citations number
46
Categorie Soggetti
Immunology
Journal title
TRENDS IN IMMUNOLOGY
ISSN journal
14714906 → ACNP
Volume
22
Issue
4
Year of publication
2001
Pages
199 - 204
Database
ISI
SICI code
1471-4906(200104)22:4<199:FRTSFA>2.0.ZU;2-S
Abstract
Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in w hich failure to switch off their inflammatory programme leads to the inappr opriate survival and retention of leukocytes within inflamed tissue.