Immunotherapeutic gene transfer into muscle

Authors
Prud'homme, GJ Lawson, BR Chang, YG Theofilopoulos, AN
Citation
Gj. Prud'Homme et al., Immunotherapeutic gene transfer into muscle, TRENDS IMMU, 22(3), 2001, pp. 149-155
Citations number
58
Categorie Soggetti
Immunology
Journal title
TRENDS IN IMMUNOLOGY
ISSN journal
14714906 → ACNP
Volume
22
Issue
3
Year of publication
2001
Pages
149 - 155
Database
ISI
SICI code
1471-4906(200103)22:3<149:IGTIM>2.0.ZU;2-E
Abstract
Immune-gene therapy can be advantageously performed with nonviral approache s. Genes that encode regulatory cytokines or inflammatory cytokine inhibito rs can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several aut oimmune diseases and is relevant to the development of effective DNA vaccin es in autoimmune diseases, infectious diseases and cancer.