The role of molecules that mediate apoptosis in T-cell selection

The T-cell repertoire is generated as a result of selection processes that happen in the thymus, The molecular basis of these processes is beginning t o be elucidated and many of the molecules identified have a role in regulat ing cell death, These molecules range from orphan nuclear receptors and tra nscription factors to cyclin-dependent kinase 2 and Bcl2 family members.