The role of molecules that mediate apoptosis in T-cell selection

Citation
O. Williams et Hjm. Brady, The role of molecules that mediate apoptosis in T-cell selection, TRENDS IMMU, 22(2), 2001, pp. 107-111
Citations number
46
Categorie Soggetti
Immunology
Journal title
TRENDS IN IMMUNOLOGY
ISSN journal
14714906 → ACNP
Volume
22
Issue
2
Year of publication
2001
Pages
107 - 111
Database
ISI
SICI code
1471-4906(200102)22:2<107:TROMTM>2.0.ZU;2-O
Abstract
The T-cell repertoire is generated as a result of selection processes that happen in the thymus, The molecular basis of these processes is beginning t o be elucidated and many of the molecules identified have a role in regulat ing cell death, These molecules range from orphan nuclear receptors and tra nscription factors to cyclin-dependent kinase 2 and Bcl2 family members.