Engineering human chromosomes for gene therapy studies

Authors
Choo, KHA
Citation
Kha. Choo, Engineering human chromosomes for gene therapy studies, TRENDS MO M, 7(6), 2001, pp. 235-237
Citations number
25
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
TRENDS IN MOLECULAR MEDICINE
ISSN journal
14714914 → ACNP
Volume
7
Issue
6
Year of publication
2001
Pages
235 - 237
Database
ISI
SICI code
1471-4914(200106)7:6<235:EHCFGT>2.0.ZU;2-N
Abstract
We now have the capability to engineer human chromosomes that could be used to deliver therapeutic genes in gene therapy studies. These vectors have t he advantages of being non-disruptive to the genome, non-immunogenic and ar e capable of carrying very large genes with all their regulatory sequences. What challenges lie ahead, and what future does this technology hold for g ene therapy?