Tsetse control has long been an important option for reducing the impact of
African trypanosomiasis but, although many effective methods have been use
d. the results have seldom proved sustainable. Developments to reduce cost
and environmental impact increasingly limit the choices available for contr
ol and the scale of operations has declined. Conversely, human trypanosomia
sis has reached epidemic proportions in some countries. Here, peg Allsopp a
rgues that those tasked with managing trypanosomiasis or committed to pover
ty alleviation in Africa should consider large-scale, area-wide tsetse cont
rol involving all proven methods, including aerial spraying and the sterile
insect technique.